GLP-1 Titration Schedule
Ramp up the right way.
See the week-by-week dose-escalation schedule for semaglutide, tirzepatide, and retatrutide — up to your target maintenance dose.
Compound
Target (maintenance) dose
Tirzepatide · weekly schedule
Weeks 1–4
2.5 mg
Weeks 5–8
5 mg
Weeks 9–12
7.5 mg
Weeks 13–16
10 mg
Weeks 17–20
12.5 mg
Week 21+
15 mg
MAINTAIN
One injection per week · step up only as tolerated · commonly-cited ranges, not medical advice.